The AIHEC Curriculum Development Program PIs worked with a course collaborator from a partnering public or private university (non-TCU), bringing SME and complementary resources to strengthen the TCU’s capacity. Through this collaboration, a course or series of modular learning units were co-developed and adapted to align with a culturally responsive curriculum that reflects Indigenous knowledge systems and community priorities. These modules integrate topics in AI/ML, data science, and health informatics, ensuring that students gain exposure to technical skills while engaging with case studies and applications relevant to tribal communities. By leveraging both the academic expertise of the partner institution and the cultural context provided by the TCU, the curriculum fosters interdisciplinary learning, upholds tribal data sovereignty, and prepares students to apply emerging technologies in ways that directly benefit their communities.